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Discovered Gene Could Block HIV

Sunday, March 09, 2008

A team of Canadian researchers led by molecular virologist Stephen Barr has discovered a gene, TRIM22, that prevents the HIV virus from assembling in a cell culture:

Barr said, "When we put this gene in cells, it prevents the assembly of the HIV virus. This means the virus cannot get out of the cells to infect other cells, thereby blocking the spread of the virus... There are always newly emerging drug-resistant strains of HIV so the push has been to develop more natural means of blocking the virus. The discovery of this gene, which is natural in our cells, might provide a different avenue. The gene prevents the assembly of the virus so in the future the idea would be to develop drugs or vaccines that can mimic the effects of this gene. We are currently trying to figure out why this gene does not work in people infected with HIV and if there is a way to turn this gene on in those individuals . We hope that our research will lead to the design of new drugs, or vaccines that can halt the person-to-person transmission of HIV and the spread of the virus in the body, thereby blocking the onset of AIDS."

Link to story.

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President Bush Signs Ryan White Reauthorization

Tuesday, December 19, 2006

Today President Bush signed the Ryan White HIV/AIDS Treatment Modernization Act, a critical life-line for over half a million low-income Americans living with HIV/AIDS. For years, the Ryan White CARE Act has been instrumental in the fight of HIV/AIDS, giving hope to those living with HIV and AIDS by providing care, services and access to lifesaving medication.

HRC President Joe Solomnese stated:

"We are pleased that a bipartisan Congress and the President were able to come together and agree on the reauthorization of the Ryan White Care Act and officially sign it into law today," said Joe Solmonese, President of the Human Rights Campaign. "This critical life-saving piece of legislation will help over a half million low-income Americans living with HIV/AIDS continue to receive the medical care they so desperately need. However, as we head into a new year and a new Congress we will aggressively push to ensure that the years of insufficient funding of this program be corrected. If our government is serious about combating this epidemic we must not allow rhetoric to mask itself as real action."


Speaker-elect Pelosi said in a statement:
"But our work is not yet done. We must remain vigilant in our fight against HIV and AIDS, recognizing that the reauthorization of the Ryan White CARE Act is only one of the many steps we must take if we are to make HIV and AIDS a distant memory. Funding has not kept pace with the number of people with AIDS or with inflation, dropping 35 percent per case since 2001. It is long past time we provide additional funding, and next year, under a Democratic Congress, we will reverse that decline."

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First Reported AIDS Case: 25th Anniversary

Friday, December 01, 2006

Twenty-five years later and the United States continues to get failing response grades in the areas of prevention, care and treatment, research and Ending AIDS-Related Stigma/Discrimination. 25 YEARS LATER and where is our government?

The Human Rights Campaign today released their report card for 2006 on the response--or major lack thereof by the United States government.




The 2006 report card is as follows:

Prevention: F
The Bush administration and the Republican congressional leadership continued to pursue policies that undermine effective prevention strategies on HIV/AIDS. The only federal funding stream for sex education in our schools remains limited to unproven and medically inaccurate abstinence-only-until-marriage programs that fail to teach youth how to protect themselves from HIV. This year, congressional leaders jettisoned language unanimously passed by the Senate mandating that these programs be medically accurate.

Furthermore, the Bush administration added additional restrictions to these federally funded abstinence-only programs mandating that "the term 'marriage' must be defined as 'only a legal union between one man and one woman as a husband and wife,' and the word 'spouse' refers only to a person of the opposite sex who is a husband or a wife." This new anti-gay restriction illustrates that these programs are not driven by public health concerns, but rather by narrow right-wing ideology.

Care and Treatment: D
Years of inadequate funding levels for the Ryan White Comprehensive AIDS Resources Emergency Act turned this year's reauthorization of this crucial program into a zero-sum game pitting states with newer and emerging HIV/AIDS epidemics against those that have been the traditional epicenters of the disease. States with newer and emerging epidemics have traditionally been short-changed by the Ryan White CARE Act and are in desperate need of more funding to provide life-saving treatment and care. However, since Congress has effectively flat-funded the program for six years, new formulas that would give these states critically needed funds would inevitably result in deep and possibly destabilizing cuts for the communities with the plurality of current cases. The Ryan White CARE Act, the payer of last resort, is a crucial part of our nation's response to the HIV/AIDS epidemic, and it is extremely disappointing that the program's reauthorization deteriorated into a formula fight, pitting low-income Americans with HIV/AIDS against each other depending on where they live.

Research: F
Last December, Congress approved a Labor-Health and Human Services appropriations bill that gave less than a 1 percent funding increase to the National Institute of Health, the smallest percentage increase since 1970. In February of this year, the president released his fiscal year 2007 budget which proposed flat-funding NIH, specifically cutting $15 million for AIDS research. Meanwhile, Congress plans on passing a continuing resolution instead of passing a Labor-HHS appropriations bill for fiscal year 2007, which means cuts for NIH. Furthermore, the House of Representatives passed a bill to reauthorize NIH that capped funding increases at 5 percent each year, which is barely enough to keep up with the inflation index for biomedical research and development.

As people living with HIV/AIDS around the world hope for the development of microbicides and other crucial preventative and treatment options-and one day a cure-cuts to AIDS research and to NIH mean that new funding for this crucial research will be extremely limited.

Global AIDS
The Bush administration and Congress have made significant steps in raising awareness and dedicating funding to fight the global AIDS pandemic. Unfortunately, many of these important initiatives have come with ideological strings attached.

In April, the U.S. Government Accountability Office released a report reviewing the expenditure of HIV prevention funds through the President's Emergency Plan For AIDS Relief. Current law mandates that 33 percent of PEPFAR prevention funds must be dedicated to abstinence-until-marriage programs. The GAO found that the abstinence-only restriction hindered the ability of HIV/AIDS organizations respond to local prevention needs. The earmark forced many programs to cut spending for mother-to-child transmission prevention, contributed to a lack of understanding of cultural norms and reduced the ability to appropriately target vulnerable populations. Instead of outsourcing our failed prevention policies overseas, U.S. global AIDS policy should allow local organizations flexibility to provide the most effective HIV prevention possible.

Ending AIDS-Related Stigma/Discrimination: F
The 2006 UNAIDS Report on the Global Epidemic asserts that understanding that homophobia is one of the key "drivers of the epidemic" is "absolutely fundamental to the long-term response to AIDS." According to these experts, ending the AIDS pandemic "will depend largely on changing the social norms, attitudes and behaviors that contribute to its expansion" through the enactment of "laws and policies that directly challenge gender inequality and bias against... men who have sex with men." This year, we add a new category to HRC's World AIDS Day report card dedicated to evaluating the government's performance in this realm.

In June of this year, on the 25th anniversary of the day that the first AIDS case was reported by the Centers for Disease Control, President Bush held a press conference to call on Congress to pass an amendment to the U.S. Constitution that would permanently ban same-sex couples from enjoying equal rights and protections of marriage. The president, surrounded by some of the most virulent anti-gay and homophobic voices in the nation, told the amendment's proponents, "I'm proud to stand with you."

And last spring, Congress stripped out of a child safety bill a provision passed by the House of Representatives by a wide, bipartisan margin to give law enforcement tools to confront hate violence against GLBT Americans, calling it "a poison pill." When our nation's leaders use same-sex couples as political scare tactics and deny law enforcement resources to confront violence driven by anti-gay violence, it is clear that they do not understand the implications that fueling homophobia has on creating a culture that is up to the task of ending HIV/AIDS.

In a message from The Human Rights Campaign regarding World AIDS Day:

"We are hopeful that with a new congressional leadership the failed policies of the past will not continue to be repeated," said Human Rights Campaign President Joe Solmonese. "Since we began this report card three years ago, the Bush administration and congressional leadership's response to this global pandemic has been grossly inadequate. The American people sent a message in these midterm elections that they want to see real actions on issues affecting people's lives, and we are optimistic that their voices will be heard in relation to the efforts to combat this disease."

Since the Human Rights Campaign issued its first World AIDS Day report card in 2004, the grades have continued to fall well below passing. The 2004 grades were: Prevention (F); Care and Treatment (D); Research (C); and Global AIDS (C). The 2005 grades were: Prevention (F); Care and Treatment (F); Research (D); and Global AIDS (C).

"As in years past, this report card does not take away from the extraordinary work that has been done by many outspoken champions fighting to put real policies in place to combat the spread of HIV/AIDS," said Solmonese. “Unfortunately, too often in the past their courageous work has been overshadowed by a government leadership that was more focused on allowing ideology to drive our response to HIV and AIDS. As the new members of Congress are sworn in, we look forward to working with a leadership that will seek real, scientific solutions to protect the well-being of all Americans."

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